Zheng Bo-an, Deng Gao-li, Dong Quan-jin, Zhao Zhong-sheng, Deng Yong-chuan
Department of Coloproctologic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Zhonghua Zhong Liu Za Zhi. 2010 Feb;32(2):111-6.
To study the E-CD and Snail expressions in colorectal cancer and their relationship with colorectal cancer invasion, metastasis and prognosis.
Immunohistochemical staining (EnVision) was used to detect the E-CD and Snail expressions in 30 normal colorectal mucosa, 30 colorectal adenoma and 142 colorectal cancer tissues.
E-CD in the normal colorectal mucosa was strongly positive expressed (90.0%), significantly higher than that in colorectal adenomas (63.3%) and colorectal cancer tissues (41.5%). E-CD expression was significantly related to tumor differentiation, invasion depth, vascular invasion, lymph node metastasis and Dukes' stage (P < 0.05), but not to the patients' age, gender, tumor size and tumor histological type (P > 0.05). The 1-, 3- and 5-year survival rates of the E-CD positive patients with colorectal cancer were significantly higher than that in E-CD negative patients. The positive expression rate of Snail in colorectal cancer tissues (52.1%) was significantly higher than that in normal colorectal mucosa (6.7%) and colorectal adenomas (26.7%, P < 0.05). The snail expression was significantly correlated to tumor histological type, differentiation, invasion depth, vascular invasion, lymph node metastasis and Duke's stage (P < 0.05), but not to patients' age, sex and tumor size (P > 0.05). The 1-, 3- and 5-year survival rates of Snail negative patients with colorectal cancer was significantly higher than that in patients with positive expression (P < 0.05). The expressions of E-CD and Snail in colorectal cancer tissues were inversely correlated (P < 0.05). Cox multivariate analysis showed that E-CD and Snail can be used as independent prognostic indicators (P < 0.05).
E-CD and Snail expressions in colorectal cancer are related to the tumor invasion, metastasis and prognosis. Low expression of E-CD and high expression of Snail are related to the advanced stage, and poor prognosis in colorectal cancer patients. E-CD and Snail can be used as independent prognostic indicators.
研究E-钙黏蛋白（E-CD）和Snail在结直肠癌中的表达及其与结直肠癌侵袭、转移和预后的关系。
采用免疫组织化学染色（EnVision法）检测30例正常结直肠黏膜、30例结直肠腺瘤和142例结直肠癌组织中E-CD和Snail的表达。
E-CD在正常结直肠黏膜中呈强阳性表达（90.0%），显著高于结直肠腺瘤（63.3%）和结直肠癌组织（41.5%）。E-CD表达与肿瘤分化程度、浸润深度、血管浸润、淋巴结转移及Dukes分期显著相关（P<0.05），但与患者年龄、性别、肿瘤大小及肿瘤组织学类型无关（P>0.05）。E-CD阳性的结直肠癌患者1年、3年和5年生存率显著高于E-CD阴性患者。Snail在结直肠癌组织中的阳性表达率（52.1%）显著高于正常结直肠黏膜（6.7%）和结直肠腺瘤（26.7%，P<0.05）。Snail表达与肿瘤组织学类型、分化程度、浸润深度、血管浸润、淋巴结转移及Duke分期显著相关（P<0.05），但与患者年龄、性别及肿瘤大小无关（P>0.05）。Snail阴性的结直肠癌患者1年、3年和5年生存率显著高于阳性表达患者（P<0.05）。结直肠癌组织中E-CD和Snail的表达呈负相关（P<0.05）。Cox多因素分析显示，E-CD和Snail可作为独立的预后指标（P<0.05）。
结直肠癌中E-CD和Snail的表达与肿瘤侵袭、转移及预后相关。E-CD低表达和Snail高表达与结直肠癌患者的晚期及不良预后相关。E-CD和Snail可作为独立的预后指标。
