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骨科创伤研究重点设定工作及研究网络的发展。

Orthopaedic trauma research priority-setting exercise and development of a research network.

机构信息

Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Surgery, University of Oxford, Kadoorie Centre for Critical Care Research and Education, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK.

出版信息

Injury. 2010 Jul;41(7):763-7. doi: 10.1016/j.injury.2010.03.026. Epub 2010 Apr 18.

Abstract

INTRODUCTION

Clinical practice should be informed by high quality evidence, of which randomised controlled trials (RCTs) are considered the gold standard. Surgical trials are inherently difficult with potential problems around clinical equipoise and participant acceptability. This is often most true with trial designs comparing operative and non-operative treatments. It is hoped that research activity can be maximised by collaborating in (a) the identification of research questions and (b) involvement in clinical trials. Development of the national research networks can be utilised to provide support for research endeavours within the orthopaedic trauma community.

AIMS

To identify and prioritise the research questions felt to be of most importance by the orthopaedic trauma community. Research studies will be considered for questions given the highest priority.

METHODS

A Delphi approach was used to determine consensus between the faculty members of the AOUK. A two round process was used to elicit the research questions and then to rank them in order of priority.

RESULTS

217 members of the AOUK Long Bone Faculty were asked to submit research questions, predominantly consultant orthopaedic surgeons. A 22% response rate generated 147 questions. These were collated and the most frequent 24 sent back out for ranking by mean scores. A 55% response to this second round identified 10 top questions. Literature searches for these 10 looked at current knowledge of the subject, completed and ongoing research projects. We also looked at the advantages and disadvantages of undertaking a study and the most appropriate methodology.

CONCLUSION

The response rates demonstrated a clear interest in developing a collaborative research strategy. This can be enhanced by utilising the support of the National Institute of Health Research Clinical Research Networks (NIHR CRN).

摘要

简介

临床实践应该以高质量的证据为依据,其中随机对照试验(RCT)被认为是金标准。外科试验具有内在的困难,可能存在临床平衡和参与者可接受性的问题。这在比较手术和非手术治疗的试验设计中尤为如此。通过合作(a)确定研究问题和(b)参与临床试验,希望可以最大限度地提高研究活动。国家研究网络的发展可以为骨科创伤社区的研究工作提供支持。

目的

确定和优先考虑骨科创伤界认为最重要的研究问题。将考虑对给予最高优先级的问题进行研究。

方法

采用德尔菲法确定 AOUK 教员之间的共识。使用两轮过程来征求研究问题,然后按优先级对其进行排序。

结果

向 AOUK 长骨学院的 217 名成员征求研究问题,主要是顾问骨科医生。22%的回复率产生了 147 个问题。这些问题被整理出来,最常见的 24 个问题被送回进行平均分数排名。对第二轮的 55%回复确定了 10 个首要问题。对这 10 个问题的文献检索研究了该主题的现有知识、已完成和正在进行的研究项目。我们还研究了进行研究的优势和劣势,以及最合适的方法。

结论

回复率表明人们对制定合作研究策略表现出浓厚的兴趣。通过利用英国国家卫生研究院临床研究网络(NIHR CRN)的支持,可以增强这种兴趣。

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