Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Expert Opin Drug Saf. 2010 Nov;9(6):971-9. doi: 10.1517/14740338.2010.484419.
Intravenous immunoglobulin (IVIg) is a biologic pharmaceutical that is widely used to treat immunodeficiency conditions and a variety of autoimmune conditions. It is under-recognized that IVIg can be associated with severe complications including death.
This review will address common mild side effects and extensively discuss the uncommon but serious complications of IVIg. Mild constitutional reactions include headache, fever and rash and severe complications include anaphylaxis, acute renal failure, stroke and myocardial infarction. IVIg has been used to treat autoimmune illnesses for ~30 years and the literature since then is reviewed with special attention to reports in the last 10 years that detail the serious adverse events.
The reader will understand that mild side effects are common and that these can be ameliorated with pre-treatment medications. They will also become familiar with the risk factors for serious complications so that careful patient and IVIg product selection will result in fewer poor outcomes.
IVIg is quite safe across age groups although serious adverse reactions occur particularly in elderly individuals with multiple cardiovascular risk factors and those with preexisting renal failure.
静脉注射免疫球蛋白（IVIg）是一种广泛用于治疗免疫缺陷和各种自身免疫性疾病的生物制药。人们认识不足的是，IVIg 可能会引起严重并发症，包括死亡。
本综述将讨论常见的轻微副作用，并广泛讨论 IVIg 不常见但严重的并发症。常见的轻微全身反应包括头痛、发热和皮疹，严重的并发症包括过敏反应、急性肾衰竭、中风和心肌梗死。IVIg 已用于治疗自身免疫性疾病约 30 年，本文综述了自那时以来的文献，特别关注了过去 10 年详细报告严重不良事件的文献。
读者将了解到常见的轻微副作用，并且可以通过预先治疗药物来减轻这些副作用。他们还将熟悉严重并发症的危险因素，因此仔细选择患者和 IVIg 产品将减少不良结局的发生。
IVIg 在各个年龄段都相当安全，尽管严重不良反应尤其发生在有多种心血管危险因素和既往肾衰竭的老年患者中。
