Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI 02912, USA.
J Anxiety Disord. 2010 Aug;24(6):559-64. doi: 10.1016/j.janxdis.2010.03.015. Epub 2010 Apr 2.
Previous studies have not compared Health-related Quality of Life (HR-QoL) across all DSM-IV anxiety disorders and comorbid conditions. We compared the effects of each anxiety disorder on HR-QoL, controlling for demographic variables, medical conditions, and comorbid Axis I disorders. Data are obtained from the Primary Care Anxiety Project (PCAP), a naturalistic, longitudinal study of anxiety disorders in 539 primary care patients. Each of the anxiety disorders was associated with worse self-reported physical and mental functioning compared to general population means. While all of the anxiety disorders were univariate predictors of specific domains of HR-QoL, only presence of Post-traumatic Stress Disorder (PTSD) and comorbid Depressive Disorder (MDD) uniquely predicted worse functioning on both self-report and interview measures. The current study extends previous research by showing that different anxiety disorders and comorbid conditions may be associated with impairment in specific domains of HR-QoL.
先前的研究并未比较所有 DSM-IV 焦虑障碍和共病情况的健康相关生活质量 (HR-QoL)。我们比较了每种焦虑障碍对 HR-QoL 的影响,同时控制了人口统计学变量、医疗状况和共病轴 I 障碍。数据来自初级保健焦虑项目 (PCAP),这是一项对 539 名初级保健患者焦虑障碍的自然主义、纵向研究。与一般人群平均值相比,每种焦虑障碍都与自我报告的身体和心理功能更差有关。虽然所有的焦虑障碍都是 HR-QoL 特定领域的单变量预测因素,但只有创伤后应激障碍 (PTSD) 和共病抑郁障碍 (MDD) 的存在才独特地预测了自我报告和访谈测量中功能更差。本研究通过显示不同的焦虑障碍和共病情况可能与 HR-QoL 的特定领域受损有关,扩展了先前的研究。