非小细胞肺癌患者的手术治疗结果的时间趋势。
Time trends of surgical outcome in patients with non-small cell lung cancer.
机构信息
Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan.
出版信息
J Thorac Oncol. 2010 Jun;5(6):825-9. doi: 10.1097/JTO.0b013e3181d5e47f.
PURPOSE
A surgical resection is a potentially curative treatment for non-small cell lung cancer (NSCLC). This study investigated the time trends of the surgical outcome in patients with NSCLC.
METHODS
This study clinicopathologically evaluated 1487 patients who had undergone a resection for NSCLC between 1979 and 2008 during the five periods of 1979-1988, 1989-1993, 1994-1998, 1999-2003, and 2004-2008.
RESULTS
The number of patients who underwent a resection during the five respective periods increased: 167, 261, 248, 382, and 429. The percentage of pathologic stage IA lung cancers was 16.2, 21.5, 23.0, 38.5, and 52.0% in each period, respectively, and it has risen rapidly in recent years. The percentage of adenocarcinoma has also progressively increased during each period: 49.1, 52.1, 54.7, 62.8, and 69.7%, respectively. The diameter of the tumors resected during each period was 36, 37, 38, 33, and 26 mm, respectively, showing that the tumor tended to be diagnosed at an increasingly smaller size. The postoperative 5-year survival rates during the five periods improved markedly: 34.1, 44.0, 44.9, 65.4, and 76.5%, respectively. Patients with pathologic stage IA lung cancer also exhibited increasingly higher 5-year survival rates during the five periods: 70.0, 71.2, 80.4, 89.2, and 88.7%, respectively.
CONCLUSION
The prognosis of NSCLC patients has remarkably improved in recent years. The increase in the number of patients with adenocarcinoma in the early stage is thought to have strongly contributed to the favorable results. Thus, early diagnosis remains a key factor for improving the survival of lung cancer patients after surgical treatment.
目的
手术切除是非小细胞肺癌（NSCLC）的潜在治愈性治疗方法。本研究调查了 NSCLC 患者手术治疗结果的时间趋势。
方法
本研究对 1979 年至 2008 年间接受 NSCLC 切除术的 1487 例患者进行了临床病理评估，这些患者分为五个时期：1979-1988 年、1989-1993 年、1994-1998 年、1999-2003 年和 2004-2008 年。
结果
五个时期接受手术治疗的患者数量分别为：167、261、248、382 和 429。各期病理分期 IA 肺癌的比例分别为 16.2%、21.5%、23.0%、38.5%和 52.0%，近年来迅速上升。腺癌的比例在每个时期也逐渐增加：49.1%、52.1%、54.7%、62.8%和 69.7%，分别。每个时期切除的肿瘤直径分别为 36、37、38、33 和 26mm，表明肿瘤越来越小。五个时期的术后 5 年生存率显著提高：34.1%、44.0%、44.9%、65.4%和 76.5%，分别。病理分期 IA 肺癌患者的 5 年生存率也在五个时期逐渐提高：70.0%、71.2%、80.4%、89.2%和 88.7%，分别。
结论
近年来 NSCLC 患者的预后显著改善。早期腺癌患者数量的增加被认为是取得良好结果的主要原因。因此，早期诊断仍然是提高肺癌患者手术后生存的关键因素。
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