Maris P
Centre national d'études vétérinaires et alimentaires, laboratoire des médicaments vétérinaires, Fougères, France.
Ann Rech Vet. 1991;22(1):11-23.
The sensitivity of 701 Gram negative strains, representing 16 species or bacterial genera, towards 4 antiseptics (cetrimide, chlorhexidine, hexachlorophene, mercuric chloride) and 6 antibiotics (ampicillin, streptomycin, erythromycin, chloramphenicol, kanamycin, tetracycline) was analysed. For 3 antiseptics (cetrimide, chlorhexidine, mercuric chloride) minimal inhibitory concentration distribution showed strains to be heterogeneous, particularly in the group Pseudomonas. Most strains were resistant to antibiotics. The statistical analysis of correlation showed positive resistance links between antiseptics (cetrimide, chlorhexidine, hexachlorophene) or between these antiseptics and antibiotics for S marcescens and Alcaligenes. Many strains proved resistant, at the same time, to mercuric chloride and to several antibiotics. These associations of resistance suggest either a common mechanism of action or a crossed resistance.
分析了代表16个菌种或细菌属的701株革兰氏阴性菌对4种防腐剂（溴化十六烷基三甲铵、洗必泰、六氯酚、氯化汞）和6种抗生素（氨苄青霉素、链霉素、红霉素、氯霉素、卡那霉素、四环素）的敏感性。对于3种防腐剂（溴化十六烷基三甲铵、洗必泰、氯化汞），最小抑菌浓度分布显示菌株具有异质性，尤其是在假单胞菌属组中。大多数菌株对抗生素耐药。相关性统计分析表明，对于粘质沙雷氏菌和产碱菌，防腐剂（溴化十六烷基三甲铵、洗必泰、六氯酚）之间或这些防腐剂与抗生素之间存在正抗性联系。许多菌株同时对氯化汞和几种抗生素耐药。这些抗性关联表明要么存在共同的作用机制，要么存在交叉耐药性。
