基于棕榈油的二脂肪酰基硫脲的化学合成与表征

Chemical synthesis and characterization of palm oil-based difatty acyl thiourea.

作者信息

Hoidy Wisam H, Ahmad Mansor B, Al-Mulla Emad A Jaffar, Yunus Wan Zin Wan, Ibrahim Nor azowa Bt

机构信息

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia.

出版信息

J Oleo Sci. 2010;59(5):229-33. doi: 10.5650/jos.59.229.

DOI:10.5650/jos.59.229

PMID:20431238

Abstract

Difatty acyl thiourea (DFAT), which has biological activities as antibiotics and antifungal, has been synthesized from palm oil and thiourea using sodium ethoxide as catalyst. Ethyl fatty ester (EFE) and glycerol were produced as by-products. The synthesis was carried out by reflux palm oil with thiourea in ethanol. In this process, palm oil converted to about 81% pure DFAT after 11 hour and molar ratio of thiourea to palm oil was 6.0: 1 at 78 degrees C. Elemental analysis, Fourier transform iInfrared (FTIR) spectroscopy and (1)H nuclear magnetic resonance (NMR) technique were used to characterize both DFAT and EFE.

摘要

二脂肪酰基硫脲（DFAT）具有抗生素和抗真菌的生物活性，它是由棕榈油和硫脲在乙醇钠作为催化剂的条件下合成的。同时还产生了副产物脂肪酸乙酯（EFE）和甘油。该合成反应是通过在乙醇中使棕榈油与硫脲回流进行的。在此过程中，在78摄氏度下，11小时后棕榈油转化为纯度约81%的DFAT，硫脲与棕榈油的摩尔比为6.0:1。采用元素分析、傅里叶变换红外（FTIR）光谱和氢核磁共振（¹H NMR）技术对DFAT和EFE进行了表征。