中性粒细胞炎症——哮喘严重程度的指标
[Neutrophilic inflammation--indicative of asthma severity].
作者信息
Grigoraş Adriana, Grigoraş Constantin-Cristian, Mihaescus Traian, Floarea-Strat Alina, Andriescu Corina, Cotutiu Coriolan
机构信息
Universitatea de Medicină si Farmacie Gr. T. Popa, Iaşi.
出版信息
Pneumologia. 2010 Jan-Mar;59(1):13-8.
UNLABELLED
Our main aim in this study was to investigate the number of neutrophils at the bronchial mucosae level in patients diagnosed with bronchial asthma.
MATERIAL AND METHODS
We examined a number of 21 patients with different level of severity of asthma (according to GINA). Fragments of bronchial mucosae were obtained through fiberbronchoscopy, prepared for histological examination for performing the immune staining with anti-elastase antibodies.
RESULTS
We found significantly higher number of neutrophils at microscopic examination in the patients with severe asthma than in healthy subjects or mild asthma subjects (r = 0.79, p < 0.01).
CONCLUSION
The results of this study suggest that neutrophils can be considered a specific lesion in patients with severe bronchial asthma.
未标注
本研究的主要目的是调查诊断为支气管哮喘的患者支气管黏膜水平的中性粒细胞数量。
材料与方法
我们检查了21例不同哮喘严重程度（根据全球哮喘防治创议）的患者。通过纤维支气管镜获取支气管黏膜碎片，准备进行组织学检查，用抗弹性蛋白酶抗体进行免疫染色。
结果
我们发现在显微镜检查中，重度哮喘患者的中性粒细胞数量明显高于健康受试者或轻度哮喘受试者（r = 0.79，p < 0.01）。
结论
本研究结果表明，中性粒细胞可被视为重度支气管哮喘患者的一种特异性病变。
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