Suppr超能文献

Hox 基因与脊椎动物身体模式的区域构成。

Hox genes and regional patterning of the vertebrate body plan.

机构信息

Instituto Gulbenkian de Ciência, Oeiras, Portugal.

出版信息

Dev Biol. 2010 Aug 1;344(1):7-15. doi: 10.1016/j.ydbio.2010.04.024. Epub 2010 May 7.

Abstract

Several decades have passed since the discovery of Hox genes in the fruit fly Drosophila melanogaster. Their unique ability to regulate morphologies along the anteroposterior (AP) axis (Lewis, 1978) earned them well-deserved attention as important regulators of embryonic development. Phenotypes due to loss- and gain-of-function mutations in mouse Hox genes have revealed that the spatio-temporally controlled expression of these genes is critical for the correct morphogenesis of embryonic axial structures. Here, we review recent novel insight into the modalities of Hox protein function in imparting specific identity to anatomical regions of the vertebral column, and in controlling the emergence of these tissues concomitantly with providing them with axial identity. The control of these functions must have been intimately linked to the shaping of the body plan during evolution.

摘要

自果蝇中的 Hox 基因被发现以来,已经过去了几十年。它们沿前后轴(AP)调节形态的独特能力(Lewis,1978)使它们作为胚胎发育的重要调节因子而备受关注。由于小鼠 Hox 基因突变导致的表型失活和获得功能的突变表明,这些基因的时空调控表达对于胚胎轴向结构的正确形态发生至关重要。在这里,我们回顾了最近关于 Hox 蛋白功能的新见解,这些见解赋予了脊柱解剖区域的特定身份,并控制了这些组织的出现,同时赋予了它们轴向身份。这些功能的控制必须与进化过程中身体形态的塑造密切相关。

相似文献

1
Hox genes and regional patterning of the vertebrate body plan.
Dev Biol. 2010 Aug 1;344(1):7-15. doi: 10.1016/j.ydbio.2010.04.024. Epub 2010 May 7.
2
40 years of the homeobox: mechanisms of Hox spatial-temporal collinearity in vertebrates.
Development. 2024 Aug 15;151(16). doi: 10.1242/dev.202508. Epub 2024 Aug 21.
3
Hox patterning of the vertebrate axial skeleton.
Dev Dyn. 2007 Sep;236(9):2454-63. doi: 10.1002/dvdy.21286.
5
Hox patterning of the vertebrate rib cage.
Development. 2007 Aug;134(16):2981-9. doi: 10.1242/dev.007567. Epub 2007 Jul 11.
6
Shaping segments: Hox gene function in the genomic age.
Bioessays. 2008 Oct;30(10):965-79. doi: 10.1002/bies.20823.
8
The Hox code responsible for the patterning of the anterior vertebrae in zebrafish.
Development. 2024 Jul 15;151(14). doi: 10.1242/dev.202854. Epub 2024 Jul 12.
9
Comparative analysis of Hox downstream genes in Drosophila.
Development. 2007 Jan;134(2):381-92. doi: 10.1242/dev.02746. Epub 2006 Dec 13.
10
The bithorax complex of Drosophila an exceptional Hox cluster.
Curr Top Dev Biol. 2009;88:1-33. doi: 10.1016/S0070-2153(09)88001-0.

引用本文的文献

2
Generation of Hoxa11-3XFLAG and Hoxd11-3XFLAG alleles to investigate Hox11 genome-wide binding.
Dev Biol. 2025 Aug;524:210-218. doi: 10.1016/j.ydbio.2025.05.013. Epub 2025 May 17.
3
Role of Homeobox A1 in Airway Epithelial Generation from Human Airway Basal Cells.
Cells. 2025 Apr 5;14(7):549. doi: 10.3390/cells14070549.
4
7
Porcine myogenesis in cloned wildtype and MYF5/MYOD/MYF6-null porcine embryo.
Commun Biol. 2025 Feb 11;8(1):217. doi: 10.1038/s42003-025-07648-1.
8
Does fast running limit numerical variability of the vertebral column in rabbits and hares (Leporidae: Lagomorpha)?
R Soc Open Sci. 2025 Jan 29;12(1):241813. doi: 10.1098/rsos.241813. eCollection 2025 Jan.
10
Loss of Hoxa5 function affects Hox gene expression in different biological contexts.
Sci Rep. 2024 Dec 28;14(1):30903. doi: 10.1038/s41598-024-81867-0.

本文引用的文献

1
The numbers of vertebrae in primates.
Proc Am Philos Soc. 1945;89:601-26.
3
Changes in Hox genes' structure and function during the evolution of the squamate body plan.
Nature. 2010 Mar 4;464(7285):99-103. doi: 10.1038/nature08789.
4
Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.
Dev Cell. 2009 Oct;17(4):516-26. doi: 10.1016/j.devcel.2009.08.010.
5
6
Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.
Dev Biol. 2009 Nov 1;335(1):156-65. doi: 10.1016/j.ydbio.2009.08.020. Epub 2009 Aug 28.
7
Hox genes and vertebrate axial pattern.
Curr Top Dev Biol. 2009;88:257-78. doi: 10.1016/S0070-2153(09)88009-5.
8
Hox, Cdx, and anteroposterior patterning in the mouse embryo.
Curr Top Dev Biol. 2009;88:235-55. doi: 10.1016/S0070-2153(09)88008-3.
9
Establishment of Hox vertebral identities in the embryonic spine precursors.
Curr Top Dev Biol. 2009;88:201-34. doi: 10.1016/S0070-2153(09)88007-1.
10
Evolution of the turtle body plan by the folding and creation of new muscle connections.
Science. 2009 Jul 10;325(5937):193-6. doi: 10.1126/science.1173826.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验