Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Med Eng Phys. 2010 Jul;32(6):653-61. doi: 10.1016/j.medengphy.2010.04.006. Epub 2010 May 1.
Osteoporotic spinal fractures are a major concern in ageing Western societies. This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro-structural (internal trabecular bone core) levels. Model predictions were verified against experimental data, and found to provide a reasonably good representation of the mechanics of the osteoporotic vertebral body. This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine.
骨质疏松性脊柱骨折是老龄化西方社会的主要关注点。本研究开发了一个骨质疏松性腰椎体的多尺度有限元（FE）模型，以研究在明显（整个椎体）和微观结构（内部小梁骨核心）水平上的椎体压缩骨折的力学。模型预测经过实验数据验证，结果表明该模型能够合理地反映骨质疏松性椎体的力学特性。这种新的建模方法将允许详细研究骨质疏松症中小梁骨丢失如何影响腰椎的椎体刚度和强度。
