Department of Mechanical Engineering and Science, Kyoto University, Yoshida-hommachi, Sakyo, Kyoto 606-8501, Japan.
Philos Trans A Math Phys Eng Sci. 2010 Jun 13;368(1920):2669-82. doi: 10.1098/rsta.2010.0073.
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial fluid flow in the lacuno-canalicular system; this flow induces shear stress on the osteocytic process membrane that is known to stimulate the osteocytes. In this sense, the osteocytes behave as mechanosensors and deliver mechanical information to neighbouring cells through the intercellular communication network. In this study, bone remodelling is assumed to be regulated by the mechanical signals collected by the osteocytes. From the viewpoint of multi-scale biomechanics, we propose a mathematical model of trabecular bone remodelling that takes into account the osteocytic mechanosensory network system. Based on this model, a computational simulation of trabecular bone remodelling was conducted for a single trabecula under cyclic uniaxial loading, demonstrating functional adaptation to the applied mechanical loading as a load-bearing construct.
在骨骼的功能适应性重塑过程中，被认为在机械敏感系统中起重要作用的是陷窝-小管系统中的骨细胞。在动态负荷下，骨基质变形会在陷窝-小管系统中产生间质液流；这种流动会对骨细胞突起膜产生切变应力，已知这种应力会刺激骨细胞。从这个意义上说，骨细胞表现为机械感受器，并通过细胞间通讯网络向邻近细胞传递机械信息。在这项研究中，假设骨重塑是由骨细胞收集的机械信号调节的。从多尺度生物力学的角度出发，我们提出了一个考虑骨细胞机械敏感网络系统的小梁骨重塑的数学模型。基于该模型，对单根小梁在循环单轴加载下的小梁骨重塑进行了计算模拟，证明了作为承重结构对施加的机械载荷的功能适应性。
