Disposition kinetics of sparfloxacin in healthy, hepatopathic, and nephropathic conditions in chicken after single intravenous administration.

OBJECTIVE

To study the variation of disposition kinetic values of sparfloxacin in healthy, hepatopathic, and nephropathic chickens after a single intravenous administration.

MATERIALS AND METHODS

Hepatotoxicity was induced by the administration of paracetamol (500 mg / kg / day, p.o. for seven days) and nephrotoxicity by uranyl nitrate (2.0 mg / kg / day dissolved in distilled water, i.v. for four days) in chickens. Disposition kinetic studies of sparfloxacin were investigated in healthy as well as hepatopathic and nephropathic birds after a single intravenous administration at 40 mg / kg body weight.

RESULTS

Maximum plasma concentration detected at 0.16 hour was 31.25 +/- 2.95, 61.95 +/-1.85, and 99.86 +/- 2.21 mug / ml in healthy, hepatopathic, and nephropathic group, respectively. The drug could not be detected in the plasma of healthy birds beyond 12-hour period, while the same was detectable for 72 hour in the plasma of hepatopathic and nephropathic birds. The concentration of sparfloxacin was significantly (P < 0.01) higher in all the samples of hepathopathic and nephropathic birds compared to healthy birds. All the kinetic values were increased (P < 0.01) in the hepatopathic and nephropathic birds, except Vd(area) and Cl(B) values in hepatopathic Birds; while beta and Cl(B) values nephropathic birds were decreased significantly than that of healthy birds.

CONCLUSIONS

The dose of sparfloxacin may be reduced in hepatopathic as well as nephropathic birds.