1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy.

作者信息

Bhatt Harshesh, Kashyap Maruthi, Bhavesh Neel Sarovar

机构信息

Structural and Computational Biology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India.

出版信息

Biomol NMR Assign. 2010 Oct;4(2):143-5. doi: 10.1007/s12104-010-9229-6. Epub 2010 May 5.

DOI:10.1007/s12104-010-9229-6

PMID:20443086

Abstract

BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca(2+). Here, we report sequence-specific (1)H, (13)C, and (15)N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.

摘要