Miyabe-Nishiwaki T, Kaneko A, Nishiwaki K, Watanabe A, Watanabe S, Maeda N, Kumazaki K, Morimoto M, Hirokawa R, Suzuki J, Ito Y, Hayashi M, Tanaka M, Tomonaga M, Matsuzawa T
Center for Human Evolution Modeling Research, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan.
J Med Primatol. 2010 Oct;39(5):336-46. doi: 10.1111/j.1600-0684.2010.00415.x.
A 24-year-old, male chimpanzee (Pan troglodytes) developed acute tetraparesis. Magnetic resonance imaging showed a diffuse T2-weighted hyperintensive lesion, indicating inflammation at the C1-2 level. All infective, autoimmune, and vascular investigations were unremarkable.
The chimpanzee's condition most resembled acute transverse myelitis (ATM) in humans. The chimpanzee was in severe incapacitated neurological condition with bedridden status and required 24-hour attention for 2 months followed by special care for over a year. Initially, corticosteroid therapy was performed, and his neurological symptoms improved to some extent; however, the general condition of the chimpanzee deteriorated in the first 6 months after onset. Pressure ulcers had developed at various areas on the animal's body, as the bedridden status was protracted. Supportive therapy was continued, and the general condition, appetite, mobility, and pressure ulcers have slowly but synergistically recovered over the course of 2 years.
一只24岁的雄性黑猩猩（黑猩猩属）出现急性四肢轻瘫。磁共振成像显示C1 - 2水平有弥漫性T2加权高信号病变，提示炎症。所有感染性、自身免疫性和血管方面的检查均无异常。
这只黑猩猩的病情最类似于人类的急性横贯性脊髓炎（ATM）。这只黑猩猩处于严重的神经功能失能状态，卧床不起，在2个月内需要24小时护理，随后在一年多的时间里需要特别护理。最初进行了皮质类固醇治疗，其神经症状有一定程度的改善；然而，黑猩猩在发病后的前6个月里整体状况恶化。由于长期卧床，动物身体的各个部位出现了压疮。继续进行支持性治疗，在2年的时间里，黑猩猩的整体状况、食欲、活动能力和压疮都缓慢但协同地得到了恢复。
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