成年马重复口服给药后伏立康唑在七种体液中的分布情况。

Distribution of voriconazole in seven body fluids of adult horses after repeated oral dosing.

作者信息

Passler N H, Chan H-M, Stewart A J, Duran S H, Welles E G, Lin H-C, Ravis W R

机构信息

Department of Clinical Sciences, College of Veterinary Medicine, JT Vaughan Large Animal Teaching Hospital, Auburn University, AL 36849-2900, USA.

出版信息

J Vet Pharmacol Ther. 2010 Feb;33(1):35-41. doi: 10.1111/j.1365-2885.2009.01099.x.

DOI:10.1111/j.1365-2885.2009.01099.x

PMID:20444023

Abstract

The purpose of this study was to assess safety and alterations in body fluid concentrations of voriconazole in normal horses on days 7 and 14 following once daily dose of 4 mg/kg of voriconazole orally for 14 days. Body fluid drug concentrations were determined by the use of high performance liquid chromatography (HPLC). On day 7, mean voriconazole concentrations of plasma, peritoneal, synovial and cerebrospinal fluids, aqueous humor, epithelial lining fluid (ELF), and urine were 1.47 +/- 0.63, 0.61 +/- 0.22, 0.70 +/- 0.20, 0.62 +/- 0.26, 0.55 +/- 0.32, 79.45 +/- 69.4, and 1.83 +/- 0.44 microg/mL respectively. Mean voriconazole concentrations in the plasma, peritoneal, synovial and cerebrospinal fluids, aqueous humor, ELF and urine on day 14 were 1.60 +/- 0.37, 1.02 +/- 0.27, 0.86 +/- 0.25, 0.64 +/- 0.21, 0.68 +/- 0.13, 47.76 +/- 45.4 and 3.34 +/- 2.17 respectively. Voriconazole concentrations in the bronchoalveolar cell pellet were below the limit of detection. There was no statistically significant difference between voriconazole concentrations of body fluids when comparing days 7 and 14. Results indicated that voriconazole distributes widely into body fluids.

摘要

本研究的目的是评估正常马匹在连续14天每日口服4mg/kg伏立康唑后第7天和第14天的安全性以及伏立康唑在体液中的浓度变化。通过高效液相色谱法（HPLC）测定体液中的药物浓度。第7天，血浆、腹膜液、滑膜液、脑脊液、房水、上皮衬液（ELF）和尿液中伏立康唑的平均浓度分别为1.47±0.63、0.61±0.22、0.70±0.20、0.62±0.26、0.55±0.32、79.45±69.4和1.83±0.44μg/mL。第14天，血浆、腹膜液、滑膜液、脑脊液、房水、ELF和尿液中伏立康唑的平均浓度分别为1.60±0.37、1.02±0.27、0.86±0.25、0.64±0.21、0.68±0.13、47.76±45.4和3.34±2.17。支气管肺泡细胞沉淀中的伏立康唑浓度低于检测限。比较第7天和第14天时，体液中伏立康唑浓度无统计学显著差异。结果表明伏立康唑广泛分布于体液中。