惊呆的β细胞：一段简史。

The stunned beta cell: a brief history.

机构信息

Department of Internal Medicine, University of Pisa School of Medicine, 56100 Pisa, Italy.

出版信息

Cell Metab. 2010 May 5;11(5):349-52. doi: 10.1016/j.cmet.2010.04.009.

DOI:10.1016/j.cmet.2010.04.009

PMID:20444416

Abstract

beta cell dysfunction is sufficient to cause hyperglycemia; beta cell loss is not necessary but, if severe, can be sufficient and may be accompanied by intrinsic beta cell dysfunction. Clinical testing can differentiate beta cell capacity from beta cell glucose sensitivity but cannot ascribe either to relative changes in beta cell mass versus function. However, longitudinal and intervention studies indicate that beta cell glucose insensitivity (stunning) closely tracks with hyperglycemia and is, at least in part, reversible. Rescuing stunned beta cells is a key therapeutic target.

摘要

β 细胞功能障碍足以导致高血糖；β 细胞丧失并非必需，但如果严重，则可能足以导致高血糖，并且可能伴有内在的 β 细胞功能障碍。临床检测可以区分β 细胞的功能和β 细胞对葡萄糖的敏感性，但无法归因于β 细胞质量相对于功能的相对变化。然而，纵向和干预研究表明，β 细胞对葡萄糖的不敏感性（衰竭）与高血糖密切相关，至少部分是可逆的。挽救衰竭的β 细胞是一个关键的治疗靶点。