基于香豆素核心的 N-Ts-1-氮杂-1,3-丁二烯的氨催化不对称逆电子需求氮杂狄尔斯-阿尔德反应。
Aminocatalytic asymmetric inverse-electron-demand aza-Diels-Alder reaction of N-Ts-1-aza-1,3-butadienes based on coumarin cores.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Chem Commun (Camb). 2010 Apr 21;46(15):2665-7. doi: 10.1039/b925424b. Epub 2010 Feb 11.
DOI:10.1039/b925424b
PMID:20449332
Abstract
The asymmetric inverse-electron-demand aza-Diels-Alder reaction of N-Ts-1-aza-1,3-butadienes derived from 3-argiocarbonylcoumarins and acetaldehyde has been developed using chiral secondary aminocatalysis, giving tricyclic chroman-2-one derivatives in high enantioselectivities (up to 95% ee).
摘要
手性仲胺催化的 3-羰基亚肉桂酰基香豆素衍生的 N-Ts-1-氮杂-1,3-丁二烯与乙醛的不对称逆电子需求氮杂-Diels-Alder 反应，以高对映选择性（高达 95%ee）得到三环色满-2-酮衍生物。
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