Infectious Diseases, St Michael's Medical Center, 111 Central Avenue, Newark, NJ 07102, USA.
Mycopathologia. 2010 Oct;170(4):223-8. doi: 10.1007/s11046-010-9315-4. Epub 2010 May 7.
Kodamaea (Pichia) ohmeri is an unusual yeast-form fungus that has recently been identified as an important etiology of fungemia, endocarditis, cellulitis, funguria and peritonitis in immunocompromised patients. We report a case of K. ohmeri fungemia in a 34-year-old hospitalized patient with thrombophlebitis. The patient was admitted to the hospital for evaluation and management of an acquired tracheo-esophageal fistula secondary to an impacted denture. Fever developed on hospital day 22, and physical exam revealed right arm superficial thrombophlebitis at the site of the peripheral venous catheter that was confirmed by Doppler ultrasound. The peripheral vein was removed and blood cultures from hospital day 22 and 23 grew yeast species. The yeast was subsequently identified to be K. ohmeri by Vitek II and API20C and was confirmed by 18S rRNA gene sequencing. The fungemia and right arm phlebitis was successfully treated with a 2-week course of micafungin therapy. This is the first case of K. ohmeri fungemia in a patient that was successfully treated with micafungin.
科达摩拟内孢霉（毕赤酵母）是一种不常见的酵母样真菌，最近被确定为免疫功能低下患者发生真菌血症、心内膜炎、蜂窝织炎、真菌尿和腹膜炎的重要病因。我们报告了一例 34 岁住院患者因义齿嵌塞导致获得性气管食管瘘而继发血栓性静脉炎时发生的科达摩拟内孢霉真菌血症。患者因接受评估和管理因义齿嵌塞导致的后天性气管食管瘘而住院。住院第 22 天，患者出现发热，体格检查发现外周静脉导管所在的右上肢浅表血栓性静脉炎，经多普勒超声检查证实。外周静脉被移除，住院第 22 天和第 23 天的血培养长出酵母样菌种。通过 Vitek II 和 API20C 鉴定该酵母为科达摩拟内孢霉，18S rRNA 基因测序进一步证实了这一结果。该患者的真菌血症和右上肢静脉炎经 2 周的米卡芬净治疗后成功治愈。这是首例成功用米卡芬净治疗的科达摩拟内孢霉真菌血症病例。
