Mizumura Sunao
Department of Radiology, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan.
Brain Nerve. 2010 May;62(5):489-500.
Brain imaging is a nuclear medicine imaging technique that is unlike the other diagnostic imaging techniques; it provides images of brain circulation, metabolism, and neuroreceptors in vivo. Evidences of its efficacy in obtaining clinical findings of various functional diseases has been obtained through many researches and analyses of clinical cases. However, this technique is a functional imaging technique; therefore, it has some distinct drawbacks due to the lack of morphometric information. For example, images of functional brain activities, even in the absence of an organic lesion, show various distributions under different physiological conditions, and these change with growth or aging. In recent years, statistical analyses of medical images have been conducted, such as statistical image analysis with standard brain coordinates (voxel-wise) and measurement of CBF by compartment model analysis; however, there are characteristic artifacts that should be considered during these analyses. Here, I report the points to be considered during the interpretation of clinical images. SPECT images were mainly used to understand this nuclear medicine brain imaging technique and describe its drawbacks.
脑成像是一种核医学成像技术，与其他诊断成像技术不同；它能在体内提供脑循环、代谢和神经受体的图像。通过对临床病例的大量研究和分析，已获得其在获取各种功能性疾病临床发现方面有效性的证据。然而，这项技术是一种功能成像技术；因此，由于缺乏形态学信息，它存在一些明显的缺点。例如，即使在没有器质性病变的情况下，功能性脑活动图像在不同生理条件下也会显示出各种分布，并且这些分布会随着生长或衰老而变化。近年来，已经开展了医学图像的统计分析，如使用标准脑坐标进行统计图像分析（体素级）以及通过房室模型分析测量脑血流量；然而，在这些分析过程中存在一些应予以考虑的特征性伪影。在此，我报告临床图像解读过程中应考虑的要点。主要使用单光子发射计算机断层扫描（SPECT）图像来了解这种核医学脑成像技术并描述其缺点。
