[液基薄层细胞学检测在肺癌诊断中的应用]
[Application of ThinPrep cytology test in the diagnosis of lung cancer].
作者信息
Chi Qiong, Zheng Ji-yang, Dai Xin-jian, Zheng Yong-ke, Chen Shen-xian, Xu Hai-miao, Huang Xiao-ping
机构信息
Department of Respiratory Diseases, The Second People's Hospital of Wenzhou, Wenzhou 325000, China.
出版信息
Zhonghua Zhong Liu Za Zhi. 2010 Mar;32(3):221-4.
OBJECTIVE
To explore the diagnostic value of ThinPrep cytology test (TCT) in lung cancer.
METHODS
353 cases of bronchoalveolar lavage fluid (BALF) and(or) bronchial brushing cytology (192 cases from lung cancer patients and 161 cases from benign lung disease patients) were detected with TCT and method of direct smear, respectively. The sensitivity and specificity of two methods was compared.
RESULTS
The sensitivity and specificity of TCT were 39.6% and 99.4%. And which of direct smear method were 8.3% and 100%, respectively. The sensitivity of TCT was significantly higher than that of method of direct smear in the diagnosis of lung cancer (P < 0.01). There were 71 patients who underwent BALF and bronchial brushing cytology simultaneously, the sensitivity of TCT of BALF was higher than that of bronchial brushing cytology (P < 0.05). Of the 69 cases which had both TCT and histopathological results, TCT and pathology concordance rate was 84.1%.
CONCLUSION
TCT has more diagnostic value in lung cancer; BALF is more preponderant than bronchial brushing cytology by TCT in the diagnosis of lung cancer.
目的
探讨液基薄层细胞学检测（TCT）在肺癌诊断中的价值。
方法
分别采用TCT和直接涂片法对353例支气管肺泡灌洗液（BALF）和（或）支气管刷检细胞学标本（其中肺癌患者192例，良性肺疾病患者161例）进行检测，比较两种方法的灵敏度和特异度。
结果
TCT的灵敏度和特异度分别为39.6%和99.4%，直接涂片法的灵敏度和特异度分别为8.3%和100%。TCT在肺癌诊断中的灵敏度显著高于直接涂片法（P<0.01）。71例同时进行BALF和支气管刷检细胞学检查的患者中，BALF的TCT灵敏度高于支气管刷检细胞学（P<0.05）。69例同时有TCT和组织病理学结果的病例中，TCT与病理的符合率为84.1%。
结论
TCT在肺癌诊断中具有较高价值；在肺癌诊断中，BALF的TCT检测较支气管刷检细胞学更具优势。
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