Zhang Lei, Zhou Jian, Li Qing, Yu Hao-yong, Li Ming, Zhang Feng, Bao Yu-qian, Jia Wei-ping
Shanghai Clinical Center for Diabetes, Department of Endocrinology & Metabolism, Sixth People's Hospital Affiliated to Jiaotong University, Shanghai Diabetes Institute, Shanghai 200233, China.
Zhonghua Yi Xue Za Zhi. 2010 Mar 16;90(10):653-7.
To investigate the relationship between serum uric acid (UA) level and lower extremity arterial disease (LEAD) in type 2 diabetes mellitus (T2DM) subjects.
A total of 2174 T2DM individuals (1228 males, 946 females) were investigated. The case history, physical examination and biochemical tests were conducted. And LEAD was diagnosed by high-resolution ultrasound.
In women, the serum UA levels with LEAD was significantly higher than that without LEAD [(304 +/- 76) micromol/L vs (287 +/- 71) micromol/L, P < 0.01], but not in men [(332 +/- 76) micromol/L vs (328 +/- 77) micromol/L, P = 0.45]. The subjects were divided into 4 groups (groups A, B, C, D) according to sex-specific quartiles of serum UA levels (< 240 micromol/L, 240 - 284 micromol/L, 285 - 340 micromol/L and >or= 341 micromol/L in women and< 275 micromol/L, 275 - 322 micromol/L, 323 - 377 micromol/L and >or= 378 micromol/L in men). In women, the prevalence of LEAD of 4 groups were 38.56%, 44.02%, 47.54% and 50.00% respectively (P < 0.01). And the prevalence of LEAD in groups C and D was significantly higher than that in group A (P < 0.05). But in men there was no significant difference between 4 groups. After adjusting for age, duration of diabetes mellitus, smoking status, systolic blood pressure, body mass index, total cholesterol, triglyceride and C reactive protein, the serum UA levels in women was an independent risk factor associated with the prevalence of LEAD. And the odds ratios (95%CI) of sex-specific quartiles of serum UA were 1.0, 1.25 (0.87 to 1.81), 1.44 (1.01 to 2.08) and 1.59 (1.10 to 2.30) respectively.
The increase of serum UA levels is associated with LEAD in women, in addition to age, duration of diabetes mellitus, smoking status, systolic blood pressure, body mass index, total cholesterol, triglyceride and C reactive protein. Serum UA levels is an independent risk factor of LEAD in women diabetics.
探讨2型糖尿病（T2DM）患者血清尿酸（UA）水平与下肢动脉疾病（LEAD）之间的关系。
共纳入2174例T2DM患者（男性1228例，女性946例），进行病史采集、体格检查及生化检测，采用高分辨率超声诊断LEAD。
女性LEAD患者血清UA水平显著高于无LEAD者[（304±76）μmol/L对（287±71）μmol/L，P<0.01]，而男性无此差异[（332±76）μmol/L对（328±77）μmol/L，P=0.45]。根据血清UA水平的性别特异性四分位数将受试者分为4组（A、B、C、D组）（女性：<240μmol/L、240284μmol/L、285340μmol/L及≥341μmol/L；男性：<275μmol/L、275322μmol/L、323377μmol/L及≥378μmol/L）。女性4组LEAD患病率分别为38.56%、44.02%、47.54%和50.00%（P<0.01），C组和D组LEAD患病率显著高于A组（P<0.05），男性4组间无显著差异。校正年龄、糖尿病病程、吸烟状况、收缩压、体重指数、总胆固醇、甘油三酯及C反应蛋白后，女性血清UA水平是LEAD患病率的独立危险因素，血清UA水平性别特异性四分位数的比值比（95%CI）分别为1.0、1.25（0.87至1.81）、1.44（1.01至2.08）和1.59（1.10至2.30）。
除年龄、糖尿病病程、吸烟状况、收缩压、体重指数、总胆固醇、甘油三酯及C反应蛋白外，女性血清UA水平升高与LEAD相关，血清UA水平是女性糖尿病患者LEAD的独立危险因素。
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