Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri 63108, USA.
Fertil Steril. 2010 Dec;94(7):2659-64. doi: 10.1016/j.fertnstert.2010.03.077. Epub 2010 May 7.
To compare different oral ovulation induction agents in treating infertile women with polycystic ovary syndrome (PCOS).
Decision-analytic model comparing three treatment strategies using probability estimates derived from literature review and sensitivity analyses performed on the baseline assumptions.
Outpatient reproductive medicine and gynecology practices.
PATIENT(S): Infertile women with PCOS.
INTERVENTION(S): Metformin, clomiphene citrate, or metformin with clomiphene citrate.
MAIN OUTCOME MEASURE(S): Live birth.
RESULT(S): Within the baseline assumptions, combination therapy with metformin and clomiphene citrate was the preferred therapy for achieving live birth in women with PCOS. Sensitivity analysis revealed the model to be robust over a wide range of probabilities.
CONCLUSION(S): Combination therapy with metformin and clomiphene citrate should be considered as first-line treatment for infertile women with PCOS.
比较不同的口服排卵诱导剂治疗多囊卵巢综合征(PCOS)不孕妇女的效果。
使用从文献综述和对基线假设进行的敏感性分析中得出的概率估计值比较三种治疗策略的决策分析模型。
门诊生殖医学和妇科诊所。
患有 PCOS 的不孕妇女。
二甲双胍、枸橼酸氯米酚或二甲双胍联合枸橼酸氯米酚。
活产。
在基线假设下,二甲双胍联合枸橼酸氯米酚的联合治疗是 PCOS 不孕妇女实现活产的首选治疗方法。敏感性分析显示,该模型在广泛的概率范围内具有稳健性。
对于患有 PCOS 的不孕妇女,应考虑二甲双胍联合枸橼酸氯米酚的联合治疗作为一线治疗方法。