Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Dakhalia 35516, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2010 Sep 1;76(5):496-501. doi: 10.1016/j.saa.2010.04.012. Epub 2010 Apr 21.
Cr(3+), ZrO(2+), HfO(2+) and UO(2)(2+) complexes of oxalohydrazide (H(2)L(1)) and oxalyl bis(diacetylmonoxime hydrazone) [its IUPAC name is oxalyl bis(3-hydroxyimino)butan-2-ylidene)oxalohydrazide] (H(4)L(2)) have been synthesized and characterized by partial elemental analysis, spectral (IR; electronic), thermal and magnetic measurements. [Cr(L(1))(H(2)O)(3)(Cl)].H(2)O, [ZrO(HL(1))(2)].C(2)H(5)OH, [UO(2)(L(1))(H(2)O)(2)] ZrO(H(3)L(2))(Cl).2H(2)O, HfO(H(3)L(2))(Cl).2H(2)O and [UO(2)(H(2)L(2))].2H(2)O have been suggested. H(2)L(1) behaves as a monobasic or dibasic bidentate ligand while H(4)L(2) acts as a tetrabasic octadentate with the two metal centers. The molecular modeling of the two ligands have been drawn and their molecular parameters were calculated. Examination of the DNA degradation of H(2)L(1) and H(4)L(2) as well as their complexes revealed that direct contact of ZrO(H(3)L(2))(Cl).2H(2)O or HfO(H(3)L(2))(Cl).2H(2)O degrading the DNA of Eukaryotic subject. The ligands and their metal complexes were tested against Gram's positive Bacillus thuringiensis (BT) and Gram's negative (Escherichia coli) bacteria. All compounds have small inhibitory effects.
草酸酰肼（H2L1）和草酰双（二乙酰单肟酰腙）[其 IUPAC 名称为草酰双（3-亚氨基丁基）草酰酰腙]（H4L2）与 Cr(3+)、ZrO(2+)、HfO(2+) 和 UO(2)(2+)形成的配合物已经通过部分元素分析、光谱（IR；电子）、热和磁性测量来进行合成和表征。[Cr(L1)(H2O)(3)(Cl)].H2O、[ZrO(HL1)(2)].C2H5OH、[UO2(L1)(H2O)2] [ZrO(H3L2)(Cl)]（2）.2H2O、[HfO(H3L2)(Cl)]（2）.2H2O 和[UO2(H2L2)]。2H2O 已经被提出。H2L1 作为单基或双基双齿配体，而 H4L2 作为四基八齿配体，与两个金属中心配位。两个配体的分子建模已经绘制出来，并且计算了它们的分子参数。对 H2L1 和 H4L2 及其配合物的 DNA 降解进行了研究，结果表明[ZrO（H3L2）（Cl）]（2）。2H2O 或[HfO（H3L2）（Cl）]（2）。2H2O 与真核主体 DNA 直接接触降解。对革兰氏阳性苏云金芽孢杆菌（BT）和革兰氏阴性（大肠杆菌）细菌进行了配体及其金属配合物的测试。所有化合物都有较小的抑制作用。
