根据卵母细胞成熟度，多囊卵巢综合征患者和非多囊卵巢综合征患者的颗粒细胞和卵丘细胞中胰岛素样生长因子成分的 mRNA 表达模式。
mRNA expression pattern of insulin-like growth factor components of granulosa cells and cumulus cells in women with and without polycystic ovary syndrome according to oocyte maturity.
机构信息
CHA Fertility Center of Bundang CHA General Hospital, CHA Research Institute, and Graduate School of Life Science and Biotechnology, College of Medicine, CHA University, Seongnam, South Korea.
出版信息
Fertil Steril. 2010 Nov;94(6):2417-20. doi: 10.1016/j.fertnstert.2010.03.053. Epub 2010 May 8.
The mRNA expression of insulin-like growth factor (IGF) components was investigated in granulosa cells (GCs) and cumulus cells (CCs) sampled from immature and mature follicles in women with and without polycystic ovary syndrome (PCOS). Gene expression for IGF-binding protein (IGFBP) 3 in GCs definitely differed between normal women and women with PCOS, whereas increase in IGF-I and IGF receptor (IGFR) 2 mRNA in mature-follicle GCs, increase in IGF-II, IGFR-1, and IGFBP-4 mRNA in immature-follicle GCs, increase in IGFR-2 and IGFBP-2 mRNA in mature-follicle CCs, and increase IGFBP-6 mRNA in immature-follicle CCs were observed in both normal women and women with PCOS.
研究了患有和未患有多囊卵巢综合征（PCOS）的女性的不成熟和成熟卵泡中的颗粒细胞（GCs）和卵丘细胞（CCs）中胰岛素样生长因子（IGF）成分的 mRNA 表达。GCs 中的 IGF 结合蛋白（IGFBP）3 的基因表达在正常女性和 PCOS 女性之间肯定存在差异，而成熟卵泡 GCs 中的 IGF-I 和 IGF 受体（IGFR）2 mRNA 的增加、不成熟卵泡 GCs 中的 IGF-II、IGFR-1 和 IGFBP-4 mRNA 的增加、成熟卵泡 CCs 中的 IGFR-2 和 IGFBP-2 mRNA 的增加以及不成熟卵泡 CCs 中的 IGFBP-6 mRNA 的增加均在正常女性和 PCOS 女性中观察到。
Zotero 插件