Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Scheeles väg 1-A1-plan2, 171 77, Stockholm, Sweden.
Cell Mol Life Sci. 2010 Sep;67(18):3037-55. doi: 10.1007/s00018-010-0390-y. Epub 2010 May 9.
Melanocytes and Schwann cells are derived from the multipotent population of neural crest cells. Although both cell types were thought to be generated through completely distinct pathways and molecular processes, a recent study has revealed that these different cell types are intimately interconnected far beyond previously postulated limits in that they share a common post-neural crest progenitor, i.e. the Schwann cell precursor. This finding raises interesting questions about the lineage relationships of hitherto unrelated cell types such as melanocytes and Schwann cells, and may provide clinical insights into mechanisms of pigmentation disorders and for cancer involving Schwann cells and melanocytes.
黑素细胞和施万细胞来源于多能性的神经嵴细胞群体。尽管这两种细胞类型被认为是通过完全不同的途径和分子过程产生的，但最近的一项研究表明，这些不同的细胞类型在以前假设的界限之外密切相互关联，因为它们共享一个共同的神经嵴后祖细胞，即施万细胞前体细胞。这一发现提出了关于黑素细胞和施万细胞等迄今无关细胞类型的谱系关系的有趣问题，并可能为涉及施万细胞和黑素细胞的色素沉着紊乱和癌症的机制提供临床见解。
