Lapointe A-K, Hofbauer G, Anliker M, Arnold A, Binet I, Hunger R, Kempf W, Pascual M, Pelloni F, Serra A, Laffitte E
Service de dermatologie et vénéréologie, CHUV, Lausanne.
Rev Med Suisse. 2010 Apr 28;6(246):854-9.
Swiss clinical practice guidelines for skin cancer in organ transplant recipients Transplant patients have increased over the last decades. As a consequence of long-term immunosuppression, skin cancer, in particular squamous cell carcinoma (SCC), has become an important problem. Screening and education of potential organ transplant recipients (OTRs) regarding prevention of sun damage and early recognition of skin cancer are important before transplantation. Once transplanted, OTRs should be seen yearly by a dermatologist to ensure compliance with sun avoidance as well as for treatment of precancerosis and SCC. Early removal is the best treatment for SCC. Reduction of immunosuppression, switch to mTOR inhibitors and chemoprevention with acitretin may reduce the incidence of SCC. The dermatological follow-up of OTRs should be integrated into a comprehensive post-transplant management strategy.
瑞士器官移植受者皮肤癌临床实践指南 在过去几十年中,移植患者的数量有所增加。由于长期免疫抑制,皮肤癌,尤其是鳞状细胞癌(SCC),已成为一个重要问题。在移植前,对潜在器官移植受者(OTR)进行有关预防阳光损伤和早期识别皮肤癌的筛查和教育非常重要。一旦移植,OTR应每年由皮肤科医生进行检查,以确保遵守防晒措施以及对癌前病变和SCC进行治疗。早期切除是SCC的最佳治疗方法。减少免疫抑制、改用mTOR抑制剂以及使用阿维A进行化学预防可能会降低SCC的发病率。OTR的皮肤科随访应纳入全面的移植后管理策略。