异源性 CO2 激光刺激抑制与牙齿相关的体感诱发电位。

Heterotopic CO2 laser stimulation inhibits tooth-related somatosensory evoked potentials.

机构信息

Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.

出版信息

Pain Med. 2010 Jun;11(6):825-33. doi: 10.1111/j.1526-4637.2010.00855.x. Epub 2010 Apr 29.

DOI:10.1111/j.1526-4637.2010.00855.x

PMID:20456077

Abstract

BACKGROUND

The diffuse noxious inhibitory control (DNIC) effect is the neurophysiological basis for the phenomenon that heterotopic "pain inhibits pain" in remote areas of the body. The effect of DNIC is mediated by spino-bulbo-spinal loops and a final postsynaptic inhibitory mechanism. The DNIC effect depends on intensity, duration, quality, and application site of conditioning stimulation and stimulated nerve fiber-type. DNIC induced by CO(2) laser conditioning stimulation has, however, not yet been investigated, and the present study was designed to examine this.

METHODS

As the indicator of test stimulation, the late component of somatosensory evoked potentials (SEPs) induced by electrical tooth stimulation and pain intensity were examined under CO(2) laser conditioning stimulation. As the conditioning stimuli, CO(2) laser energy (lambda = 10.6 microm, spot size Ø = 2 mm) was applied to the dorsum of the left hand.

RESULTS

The maximum reductions in SEP amplitude and pain intensity evaluated using a visual analog scale were 34.7% and 28.7%, respectively during CO(2) laser conditioning stimulation. No aftereffect was observed.

CONCLUSION

The present study revealed that CO(2) laser radiation attenuated the late component of SEPs induced by electrical tooth stimulation, triggering the DNIC effect but with no aftereffect.

摘要

背景

弥散性伤害性抑制控制（DNIC）效应是身体远处异源性“疼痛抑制疼痛”现象的神经生理学基础。DNIC 的作用是通过脊髓-脑-脊髓环路和最终的突触后抑制机制来介导的。DNIC 效应取决于条件刺激和受激神经纤维类型的强度、持续时间、质量和应用部位。然而，尚未研究 CO2 激光条件刺激诱导的 DNIC，本研究旨在对此进行检验。