Endodontic Department, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Int Endod J. 2010 Jul;43(7):565-71. doi: 10.1111/j.1365-2591.2010.01711.x. Epub 2010 Apr 23.
To examine the in vivo response of dental pulps in dogs to three pulp-capping agents: calcium hydroxide (CH), mineral trioxide aggregate (MTA) and a new endodontic calcium enriched mixture (CEM) cement.
Thirty-six second and third premolar teeth in six beagle dogs were randomly assigned to three experimental groups; CH, MTA or CEM cement. Following isolation and exposure, pulp tissues were removed with a fissure bur and haemostasis achieved. The pulps were dressed with appropriate materials, and the access cavity restored with amalgam. Histological analysis was performed 8 weeks after treatment; the samples were assessed by an independent observer for calcified bridge formation, pulp vitality and pulp inflammation. The data were analysed by Kruskal-Wallis, Mann-Whitney and one-way anova tests.
The number of root canals that showed calcified bridge formation, pulp vitality and lack of inflammation was significantly higher for teeth capped with either MTA or CEM cement in comparison with CH (P < 0.05). No significant difference was found between the CEM cement and MTA in terms of calcified bridge formation, pulp vitality and lack of inflammation (P > 0.05).
Mineral trioxide aggregate and CEM cement were associated with a similar favourable biological response to pulpotomy treatment and demonstrated a more effective induction of dentinal bridge formation compared to CH.
研究三种盖髓剂（氢氧化钙（CH）、三氧化物聚合体（MTA）和新型牙髓钙强化混合物（CEM）水泥）在犬牙髓体内的体内反应。
将 6 只比格犬的 36 颗第二和第三前磨牙随机分为 3 组实验：CH、MTA 或 CEM 水泥。隔离和暴露后，用裂钻去除牙髓组织并止血。用适当的材料覆盖牙髓，并使用汞合金修复牙体腔。治疗 8 周后进行组织学分析；由独立观察者评估样本的钙化桥形成、牙髓活力和牙髓炎症情况。采用 Kruskal-Wallis、Mann-Whitney 和单因素方差分析对数据进行分析。
与 CH 相比，用 MTA 或 CEM 水泥覆盖的牙齿的钙化桥形成、牙髓活力和无炎症的根管数量明显更高（P < 0.05）。在钙化桥形成、牙髓活力和无炎症方面，CEM 水泥与 MTA 之间无显著差异（P > 0.05）。
三氧化物聚合体和 CEM 水泥与牙髓切断术治疗有类似的良好生物学反应，与 CH 相比，更有效地诱导牙本质桥形成。
