Department of Thoracic and Cardiovascular Surgery, JW Goethe University Frankfurt, Frankfurt, Germany.
Eur J Cardiothorac Surg. 2010 Nov;38(5):523-7. doi: 10.1016/j.ejcts.2010.03.006. Epub 2010 Apr 24.
The unreinforced aortic root, in bicuspid aortic valve disease, has been shown to dilate and cause recurrent regurgitation. The objective of this study was to determine whether reduction aortoplasty can reliably prevent aortic root dilatation after aortic valve repair in bicuspid disease.
A total of 66 patients, with a mean age of 41.2±12 years and with incompetent bicuspid aortic valves and concomitant dilatation of the aortic root, were included in this study. As many as 49 patients had patch augmentation of the free edge of the bicuspid aortic leaflets and reduction aortoplasty, and a further 17 patients had patch augmentation and a modified David type repair. Patients were followed up by echocardiography and clinically in yearly intervals.
At midterm (mean follow-up was 5.1 ± 2.1 years), only one patient in the reduction aortoplasty group showed aortic root dilatation, leading to significant aortic valve regurgitation. Other than that, there was no progression of regurgitation in the whole group of patients. In the David type repair group, no re-operations, progression of aortic root dilatation or recurrent regurgitation occurred. In general, there was only one death in the reduction aortoplasty group. This patient developed endocarditis after 1 year and died of acute heart failure prior to readmission to our hospital.
Both reduction aortoplasty and modified David type repair, paired with patch augmentation of the incompetent bicuspid valve, provide excellent midterm results. The reduction of the diameter of the ascending aorta by reduction aortoplasty seems to provide reliable stability that is comparable to the David type repair.
在二叶式主动脉瓣病变中,未加固的主动脉根部会扩张并导致复发性反流。本研究的目的是确定主动脉瓣修复后,主动脉根部扩张的二叶瓣病变患者行主动脉缩窄成形术是否能可靠预防主动脉根部扩张。
共纳入 66 例年龄为 41.2±12 岁的患者,这些患者均患有功能不全的二叶式主动脉瓣及伴发的主动脉根部扩张。其中 49 例患者行二叶瓣游离缘补片增强和主动脉缩窄成形术,另外 17 例患者行补片增强和改良 David 型修复术。通过超声心动图和每年一次的临床随访对患者进行随访。
在中期(平均随访时间为 5.1 ± 2.1 年),主动脉缩窄成形术组仅 1 例患者出现主动脉根部扩张,导致明显的主动脉瓣反流。除此之外,所有患者的反流均无进展。在 David 型修复组中,无再手术、主动脉根部扩张或复发性反流发生。总体而言,主动脉缩窄成形术组仅 1 例患者死亡。该患者在术后 1 年发生心内膜炎,并在因急性心力衰竭再次入院前死亡。
主动脉根部缩窄成形术和改良 David 型修复术联合功能不全的二叶瓣补片增强术均可提供良好的中期结果。主动脉缩窄成形术降低升主动脉直径的效果似乎提供了可靠的稳定性,与 David 型修复术相当。