CTX-M 型超广谱β-内酰胺酶在土耳其欧洲部分一所大学获得的社区获得性上尿路感染大肠埃希菌分离株中的研究。
CTX-M type extended spectrum beta-lactamases in Escherichia coli isolates from community acquired upper urinary tract infections at a university in the European part of Turkey.
机构信息
Trakya Universitesi Tip Fakültesi, Enfeksiyon Hastaliklari ve Klinik Mikrobiyoloji AD, Edirne, Turkiye.
出版信息
J Microbiol Immunol Infect. 2010 Apr;43(2):163-7. doi: 10.1016/S1684-1182(10)60026-6.
Extended spectrum beta-lactamase (ESBL) producing Escherichia coli has been an emerging etiologic agent in the community acquired infections. We investigated the occurrence of ESBL producing E. coli isolated from patients admitted with community acquired urinary tract infection (UTI) to the hospital of the Trakya University, Turkey during 2006. Eleven single patient isolates of E. coli harboring ESBL were identified among 30 E. coli isolated from patients admitted with symptoms corresponding to upper UTI. CTX-M type ESBLs were detected in all 11 ESBL-producers by isoelectric focusing and polymerase chain reaction screening. Sequence analysis revealed CTX-M-1 in one isolate, CTX-M-3 in three isolates and CTX-M-15 in seven isolates. ESBL-producing E. coli isolated from community acquired UTIs are widespread in the European part of Turkey.
产超广谱β-内酰胺酶（ESBL）的大肠杆菌已成为社区获得性感染的一种新兴病原体。我们研究了 2006 年在土耳其特拉基亚大学医院因社区获得性尿路感染（UTI）入院的患者中分离出的产 ESBL 大肠杆菌的发生情况。在从症状与上尿路感染相对应的患者中分离出的 30 株大肠杆菌中，鉴定出 11 株携带 ESBL 的大肠杆菌单株分离株。通过等电聚焦和聚合酶链反应筛选，在所有 11 株产 ESBL 菌中均检测到 CTX-M 型 ESBL。序列分析显示，1 株分离株产 CTX-M-1，3 株分离株产 CTX-M-3，7 株分离株产 CTX-M-15。从社区获得性 UTIs 中分离出的产 ESBL 大肠杆菌在土耳其的欧洲部分广泛存在。
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