合成、构效关系研究及[1,4']-双哌啶基-4-基-咪唑烷-2-酮衍生物作为新型 CCR5 拮抗剂的评价。

Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.

机构信息

Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, CA 94304, USA.

出版信息

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3219-22. doi: 10.1016/j.bmcl.2010.04.077. Epub 2010 Apr 22.

DOI:10.1016/j.bmcl.2010.04.077

PMID:20457517

Abstract

Elaboration of our previously disclosed spiropiperidine template led to the development of a series of novel CCR5 antagonists. Results of SAR exploration and preliminary lead characterization are described.

摘要

我们之前披露的螺哌啶模板的详细阐述导致了一系列新型 CCR5 拮抗剂的开发。本文描述了 SAR 探索和初步先导化合物特征的结果。

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合成、构效关系研究及[1,4']-双哌啶基-4-基-咪唑烷-2-酮衍生物作为新型 CCR5 拮抗剂的评价。

Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.

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合成、构效关系研究及[1,4']-双哌啶基-4-基-咪唑烷-2-酮衍生物作为新型 CCR5 拮抗剂的评价。

Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.

机构信息

出版信息

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