Yamada Tamaki, Suzuki Sadao, Fukatsu Mitsuru, Wada Tsuneya, Yoshida Takashi, Joh Takashi
Okazaki City Medical Association, Public Health Center, 1-9-1 Tatsumi-nishi, Okazaki, Aichi, Japan.
Acta Gastroenterol Belg. 2010 Jan-Mar;73(1):12-7.
The question of whether elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease evident on ultrasonography was investigated by longitudinal approach in Japanese undergoing a health checkup.
A total of 1,386 male and 3,453 female nondrinkers participating in health checkups in both 2000 and 2005 were included. Multiple logistic regression analyses were performed for 1,042 men (51.4 +/- 11.2 years old) and 3,076 women (51.8 +/- 9.2 years old) to identify independent factors for newly developed nonalcoholic fatty liver disease in 2005. Adjustment was made for age, body mass index, body mass index increase for 5 years, systolic blood pressure, triglyceridemia, fasting blood glucose, and smoking.
The prevalence of nonalcoholic fatty liver disease and body mass index, systolic blood pressure, and triglyceride were significantly higher in the participants with elevated serum uric acid, with a significant increasing trend in relation to serum uric acid quartiles. Nonalcoholic fatty liver disease was newly diagnosed in 17.4% of males and 8.2% of females, respectively, in 2005. Serum uric acid adjusted for other factors was a risk factor for nonalcoholic fatty liver disease in both sexes and quartiles 3 and 4 had significantly elevated risks. The odds ratio and 95% confidence interval for one increment of serum uric acid were 1.31 and 1.11-1.56 in men and 1.30 and 1.10-1.53 in women, respectively.
Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup.
采用纵向研究方法，对接受健康检查的日本人进行调查，以探讨血清尿酸升高是否是非酒精性脂肪性肝病（超声检查可见）的独立危险因素。
纳入2000年和2005年参加健康检查的1386名男性和3453名女性不饮酒者。对1042名男性（51.4±11.2岁）和3076名女性（51.8±9.2岁）进行多因素logistic回归分析，以确定2005年新发生的非酒精性脂肪性肝病的独立危险因素。对年龄、体重指数、5年体重指数增加量、收缩压、甘油三酯血症、空腹血糖和吸烟情况进行了校正。
血清尿酸升高的参与者中非酒精性脂肪性肝病的患病率以及体重指数、收缩压和甘油三酯均显著更高，且与血清尿酸四分位数呈显著上升趋势。2005年，分别有17.4%的男性和8.2%的女性被新诊断为非酒精性脂肪性肝病。校正其他因素后的血清尿酸是男女非酒精性脂肪性肝病的危险因素，第3和第4四分位数的风险显著升高。男性血清尿酸每增加一个单位的比值比和95%置信区间分别为1.31和1.11 - 1.56，女性为1.30和1.10 - 1.53。
血清尿酸升高是接受健康检查的日本人非酒精性脂肪性肝病的独立危险因素。
