Tiamkao Somsak, Suko Panit, Mayurasakorn Nattakarn
Division of Neurology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
J Med Assoc Thai. 2010 Apr;93(4):420-3.
Status epilepticus (SE) is one of the common neurological emergencies in adults and for which morbidity and mortality are high and associated with either inappropriate management or underlying diseases. Forty SE patients were included (23 men; 17 women) between 18 and 86 years of age. Generalized convulsive status epilepticus (GCSE) was most common (34 events, 85%) vs. non-convulsive status epilepticus (NCSE) (6 events, 15%). Nineteen patients (47.5%) had previously diagnosed neurological disorders. Antiepileptic drug withdrawal, encephalitis and alcohol-related illness were the common causes of SE. Thirteen patients (32.5%) developed refractory status epilepticus. Improper management was found in 23 events (57.5%). Outcomes of SE included death (14, 35%), complete recovery (14, 35%) and partial recovery (12, 30%). Of the patients who experienced improper management 43.5% died over against the 23.5% who died despite proper management. To improve the outcome of SE, a public information campaign on the management ofSE is needed
癫痫持续状态(SE)是成人常见的神经系统急症之一,其发病率和死亡率很高,且与管理不当或基础疾病相关。纳入了40例年龄在18至86岁之间的SE患者(23例男性;17例女性)。全身惊厥性癫痫持续状态(GCSE)最为常见(34例,85%),而非惊厥性癫痫持续状态(NCSE)为6例(15%)。19例患者(47.5%)既往被诊断患有神经系统疾病。停用抗癫痫药物、脑炎和酒精相关疾病是SE的常见病因。13例患者(32.5%)发展为难治性癫痫持续状态。在23例事件(57.5%)中发现管理不当。SE的结局包括死亡(14例,35%)、完全恢复(14例,35%)和部分恢复(12例,30%)。在管理不当的患者中,43.5%死亡,而在管理得当的情况下仍有23.5%的患者死亡。为改善SE的结局,需要开展关于SE管理的公众宣传活动