Kizawa Memorial Hospital, 590 Shimokobi, Kobi-cho, Minokamo City, Gifu, Japan.
J Invest Dermatol. 2010 Jun;130(6):1493-6. doi: 10.1038/jid.2010.77.
Because hemidesmosomes and focal contacts (FCs) play major roles in epidermal wound healing and in the pathogenesis of subepidermal blistering diseases, it is of particular importance to understand their cross-talk in the regulation of their assembly and disassembly. In this issue, Ozawa et al. demonstrate that hemidesmosome-enriched protein complex (HPC) and FC dynamics are tightly coregulated in keratinocytes undergoing migration by employing HaCat cells that express fluorescent protein-tagged beta4 integrin and alpha-actinin as markers of HPCs and FCs.
因为半桥粒和黏着斑（FCs）在表皮伤口愈合和表皮下疱病发病机制中起着重要作用，因此了解它们在调节其组装和拆卸中的相互作用尤为重要。在本期杂志中，Ozawa 等人通过使用表达荧光蛋白标记的β4 整合素和α辅肌动蛋白的 HaCat 细胞作为 HPC 和 FC 的标志物，证明了在经历迁移的角质细胞中，HPC 和 FC 的动态紧密地受到共同调控。
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