Ding Hua-Sheng, Yang Jun
Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University & Yichang Central People's Hospital, Yichang, The People's Republic of China.
Saudi Med J. 2010 May;31(5):486-9.
High mobility group box-1 (HMGB1) is a highly conserved, ubiquitous protein in the nuclei and cytoplasm of almost all cells. After binding to its receptor, HMGB1, which is derived from necrotic cells and activated macrophages/monocytes, functions as a critical mediator of inflammation and promotes tissue repair and regeneration. Many recent studies demonstrated that HMGB1 played a pivotal role in cardiovascular diseases, such as atherosclerosis, myocardial ischemia/reperfusion injury, heart failure, and myocardial infarction. In this review, we focus on HMGB1 and summarize the association of HMGB1 with cardiovascular diseases.
高迁移率族蛋白B1（HMGB1）是一种高度保守、在几乎所有细胞的细胞核和细胞质中普遍存在的蛋白质。来自坏死细胞和活化巨噬细胞/单核细胞的HMGB1与其受体结合后，作为炎症的关键介质发挥作用，并促进组织修复和再生。最近的许多研究表明，HMGB1在心血管疾病中起关键作用，如动脉粥样硬化、心肌缺血/再灌注损伤、心力衰竭和心肌梗死。在本综述中，我们聚焦于HMGB1，并总结HMGB1与心血管疾病的关联。
