Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel College of Medicine, Philadelphia, Pennsylvania, USA.
Clin Infect Dis. 2010 Jul 1;51(1):107-10. doi: 10.1086/653426.
Human papillomavirus causes anal condylomata, high-grade anal intraepithelial neoplasia, and anal squamous cell cancer. We found high-grade intraepithelial neoplasia or squamous cell cancer in 75 (47%) of 159 HIV-seropositive men who have sex with men (MSM) and in 42 (26%) of 160 HIV-seronegative MSM with anal condylomata meriting surgery (P<.001, determined by use of the chi(2) test). Anal condylomata in MSM often harbor high-grade intraepithelial neoplasia and squamous cell cancer.
人乳头瘤病毒可引起肛门湿疣、高级别肛门上皮内瘤变和肛门鳞状细胞癌。我们发现,在 159 名与男性发生性关系的 HIV 血清阳性男同性恋者(MSM)中,有 75 名(47%)患有高级别上皮内瘤变或鳞状细胞癌,在 160 名患有值得手术治疗的肛门湿疣的 HIV 血清阴性 MSM 中,有 42 名(26%)患有高级别上皮内瘤变或鳞状细胞癌(P<.001,采用卡方检验确定)。MSM 中的肛门湿疣常伴有高级别上皮内瘤变和鳞状细胞癌。