英夫利昔单抗治疗复发性多软骨炎相关性难治性坏死性巩膜炎 1 例
Infliximab in a patient with refractory necrotizing scleritis associated with relapsing polychondritis.
机构信息
Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Ocul Immunol Inflamm. 2010 Jun;18(3):216-7. doi: 10.3109/09273941003624914.
PURPOSE
To describe a case of necrotizing scleritis associated with relapsing polychondritis (RP), which was treated with infliximab.
METHOD
Observational case report.
RESULTS
A 60-year-old woman presented with a red eye. She had a past medical history of nose deformity, hearing problem, and tinnitus. Ophthalmological examination disclosed necrotizing scleritis and peripheral ulcerative keratitis. RP was diagnosed. The disease progressed despite treatment with methotrexate and cyclophosphamide, but infliximab resulted in a stabilization of the disease.
CONCLUSION
Infliximab could be a new weapon to treat refractory scleritis due to RP.
目的
描述一例与复发性多软骨炎相关的坏死性巩膜炎病例，该病例接受了英夫利昔单抗治疗。
方法
观察性病例报告。
结果
一名 60 岁女性因眼红就诊。她既往有鼻畸形、听力问题和耳鸣病史。眼科检查发现坏死性巩膜炎和周边溃疡性角膜炎。诊断为复发性多软骨炎。尽管接受了甲氨蝶呤和环磷酰胺治疗，但疾病仍在进展，而英夫利昔单抗则使疾病稳定。
结论
英夫利昔单抗可能成为治疗复发性多软骨炎难治性巩膜炎的新武器。
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