Cochran Alistair J, Binder Scott, Morton Donald L
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1732, USA.
J Cutan Pathol. 2010 Apr;37 Suppl 1:54-9. doi: 10.1111/j.1600-0560.2010.01509.x.
Atypical and anomalous melanocytic lesions are tumors that cannot be determined by microscopy to be certainly benign or fully malignant. The malignant potential of these borderline lesions is unknown and logical determination of best therapy is challenging, in particular whether lymphatic mapping and sentinel node biopsy have a place in their management. Lesions that fall into this category include atypical Spitzoid lesions, atypical cellular blue nevi, combined nevi, deep penetrating nevi, ancient nevi, desmoplastic nevi, balloon cell nevi and proliferation nodules of congenital nevi. We report our experience managing patients with these problematic tumors and discuss our approaches to determining the true location of lesional cells in sentinel nodes.
非典型和异常黑素细胞病变是通过显微镜检查无法确定为肯定良性或完全恶性的肿瘤。这些临界病变的恶性潜能未知，合理确定最佳治疗方案具有挑战性，尤其是淋巴绘图和前哨淋巴结活检在其治疗中是否适用。属于这一类别的病变包括非典型Spitz样病变、非典型细胞性蓝痣、复合痣、深部浸润性痣、老年痣、促纤维增生性痣、气球细胞痣和先天性痣的增殖结节。我们报告了我们治疗这些疑难肿瘤患者的经验，并讨论了我们确定前哨淋巴结中病变细胞真实位置的方法。
