经修饰的 siRNAs 用于 PAZ 结构域研究。
Modified siRNAs for the study of the PAZ domain.
机构信息
IMDEA-Nanociencia, 28049, Madrid, Spain.
出版信息
Chem Commun (Camb). 2010 Jun 28;46(24):4270-2. doi: 10.1039/c003221b. Epub 2010 May 19.
DOI:10.1039/c003221b
PMID:20485810
Abstract
Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ domain of RISC have been tested for their effect on RNAi activity. Such modifications contribute positively to the stability of siRNAs in human serum.
摘要
为了稳定 siRNA 与 RISC 的 PAZ 结构域之间的相互作用，人们已经测试了针对化学修饰对 RNAi 活性的影响。这些修饰对 siRNA 在人血清中的稳定性有积极的贡献。
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