Miller K, Bergmann L, Albers P, Gschwend J, Jäger E, Keilholz U
Klinik für Urologie, Charité - Universitätsmedizin Berlin.
Aktuelle Urol. 2010 May;41(3):193-6. doi: 10.1055/s-0030-1247395. Epub 2010 May 18.
With the introduction of targeted therapies, a -paradigm shift for the treatment of metastatic renal cell carcinoma has taken place. The use of cytokines as the long-standing standard therapy has declined. New compounds like sunitinib, -sorafenib, bevacizumab and temsirolimus have become established as new therapeutic standards. Since mid-2009, these substances have been complemented by everolimus. An interdisciplinary consensus conference was held to discuss what criteria to consider when using these drugs (treatment sequence) and what questions remain unanswered based on the current study situation (open questions). Results from the 2008 conference provided the basis for the 2009 meeting. The results of the 2009 conference are presented as short theses.
随着靶向治疗方法的引入,转移性肾细胞癌的治疗发生了范式转变。作为长期标准疗法的细胞因子的使用已经减少。舒尼替尼、索拉非尼、贝伐单抗和替西罗莫司等新化合物已成为新的治疗标准。自2009年年中以来,依维莫司也加入了这些药物的行列。召开了一次跨学科共识会议,讨论使用这些药物时应考虑哪些标准(治疗顺序),以及根据当前的研究情况仍有哪些问题未得到解答(未解决的问题)。2008年会议的结果为2009年会议提供了基础。2009年会议的结果以简短论文的形式呈现。