Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Pharmacopsychiatry. 2010 Jul;43(5):179-83. doi: 10.1055/s-0030-1249096. Epub 2010 May 18.
The aim of this study was to investigate how frequently patients transit from general practitioner (GP) to psychiatrist care and vice versa during a first antidepressant episode and antidepressant treatment changes associated with those transitions.
Antidepressant episodes were constructed for patients (> or =18 years) initiating SSRI use in 2000 (N=10 158). Transition in care within a first treatment episode was investigated. Changes in antidepressant treatment were compared between transiting and non-transiting patients.
6.0% of patients who initiate SSRI use in GP practice transited to psychiatrist care, whereas 39.1% of those initiating use in psychiatrist care transited to GP care. Patients transiting from GP to psychiatrist care were more likely to switch to other antidepressants (RR=6.16, 95% CI: 4.90, 7.75) or to other doses (RR=4.48, 95% CI: 3.76, 5.34) than non-transiting patients. No significant differences in antidepressant treatment were found for patients transiting from psychiatric to GP care.
Approximately 9% of SSRI initiators transit in care. Transitions from GP to psychiatric care lead to antidepressant treatment changes and could potentially be used in observational studies as a disease severity indicator.
本研究旨在调查首次抗抑郁药物治疗期间,患者从全科医生(GP)转诊至精神科医生或反之的频率,以及与这些转诊相关的抗抑郁药物治疗变化。
为 2000 年开始使用 SSRI 的年龄≥18 岁的患者(N=10158)构建抗抑郁发作。调查首次治疗发作期间的护理中转情况。比较中转和非中转患者的抗抑郁药物治疗变化。
在 GP 诊所开始使用 SSRI 的患者中,有 6.0%转诊至精神科医生,而在精神科医生开始使用 SSRI 的患者中,有 39.1%转诊至 GP 诊所。从 GP 转诊至精神科的患者更有可能改用其他抗抑郁药(RR=6.16,95%CI:4.90,7.75)或其他剂量(RR=4.48,95%CI:3.76,5.34),而非中转患者。从精神科转诊至 GP 的患者,抗抑郁药物治疗无显著差异。
约 9%的 SSRI 使用者会在护理中进行转诊。从 GP 转诊至精神科会导致抗抑郁药物治疗的变化,并且在观察性研究中可以作为疾病严重程度的指标。