用聚乙二醇化牛羧基血红蛋白输血对短暂性局灶性脑缺血进行早期治疗。
Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion.
作者信息
Klaus Judith A, Kibler Kathleen K, Abuchowski Abraham, Koehler Raymond C
机构信息
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University/JHMI, 600 North Wolfe Street, Baltimore, MD 21287, USA.
出版信息
Artif Cells Blood Substit Immobil Biotechnol. 2010 Oct;38(5):223-9. doi: 10.3109/10731199.2010.488635.
Abstract
The effect of transfusion of PEGylated hemoglobin (PEG-Hb) was evaluated in anesthetized rats subjected to 2 hours of focal cerebral ischemia and 1 day of reperfusion. PEG-Hb was stored in the carboxy state (PEG-COHb) to reduce autooxidation and increase the shelf life. Transfusion of 10 ml/kg of PEG-COHb at 20 minutes of ischemia did not alter arterial blood pressure or increase red cell flux in the ischemic core. Plasma hemoglobin increased to only 0.6 g/dL, yet infarct volume was markedly decreased and neurological deficits were improved. We conclude that early topload transfusion of PEG-COHb protects the brain from ischemic stroke.
摘要
在接受2小时局灶性脑缺血和1天再灌注的麻醉大鼠中评估了聚乙二醇化血红蛋白（PEG-Hb）输血的效果。PEG-Hb以羧基状态（PEG-COHb）储存，以减少自氧化并延长保质期。在缺血20分钟时输注10 ml/kg的PEG-COHb不会改变动脉血压，也不会增加缺血核心区的红细胞流量。血浆血红蛋白仅增加到0.6 g/dL，但梗死体积明显减小，神经功能缺损得到改善。我们得出结论，早期大量输注PEG-COHb可保护大脑免受缺血性中风的影响。
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2
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3
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