6,7-二羟基-2-二甲基氨基四氢萘（TL-99）刺激突触后D-1和D-2多巴胺受体。
6,7-Dihydroxy-2-dimethylaminotetralin (TL-99) stimulates postjunctional D-1 and D-2 dopamine receptors.
作者信息
Kebabian J W, Miyazaki K, Grewe C W
机构信息
Biochemical Neuropharmacology Section, Experimental Therapeutics Branch, NINCDS, NIH, Bethesda, MD 20205, U.S.A.
出版信息
Neurochem Int. 1983;5(2):227-9. doi: 10.1016/0197-0186(83)90118-3.
6,7-Dihydroxy-2-dimethylaminotetralin (TL-99) mimicks the ability of dopamine either to enhance adenylate cyclase activity in homogenates of goldfish retina or to inhibit adenylate cyclase activity in homogenates of the intermediate lobe (IL) of the rat pituitary gland previously treated with cholera toxin. Both the dopamine stimulated adenylate cyclase activity in the fish retina and the dopamine inhibited adenylate cyclase activity in the rat IL are associated with cells postjunctional to the dopaminergic neurons innervating these tissues. Therefore, the present data do not support the contention that TL-99 is a selective presynaptic dopamine receptor agonist.
6,7 - 二羟基 - 2 - 二甲基氨基四氢萘（TL - 99）可模拟多巴胺的作用，既能增强金鱼视网膜匀浆中的腺苷酸环化酶活性，也能抑制预先用霍乱毒素处理过的大鼠垂体中间叶（IL）匀浆中的腺苷酸环化酶活性。多巴胺刺激的鱼视网膜腺苷酸环化酶活性以及多巴胺抑制的大鼠中间叶腺苷酸环化酶活性均与支配这些组织的多巴胺能神经元的节后细胞相关。因此，目前的数据不支持TL - 99是一种选择性突触前多巴胺受体激动剂这一论点。
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