大鼠脑中的胆囊收缩素八肽（CCK 26 - 33）、非硫酸化八肽和四肽（CCK 30 - 33）：高压液相色谱法（HPLC）和放射免疫分析法（RIA）分析
Cholecystokinin octapeptide (CCK 26-33), nonsulfated octapeptide and tetrapeptide (CCK 30-33) in rat brain: Analysis by high pressure liquid chromatography (HPLC) and radioimmunoassay (RIA).
作者信息
Frey P
机构信息
Wander Research Institute, (a Sandoz Research Unit), Wander Ltd., P.O. Box 2747, CH-3001 Berne, Switzerland.
出版信息
Neurochem Int. 1983;5(6):811-5. doi: 10.1016/0197-0186(83)90108-0.
Cholecystokinin carboxyterminal octa- and tetrapeptide concentrations have been measured in rat brain by a combination of high pressure liquid chromatography and radioimmunoassay. The sulfated octapeptide is the predominant form of Cholecystokinin in rat brain (approx. 80%). The concentration of the tetrapeptide represents 5-10% of that of the sulfated octapeptide in molar terms, depending upon the brain region. In addition to the tetrapeptide, a peptide with the properties of Cholecystokinin octapeptide in its nonsulfated form could be detected in concentrations similar to those of the tetrapeptide.
通过高压液相色谱法和放射免疫分析法相结合的方法，已测定了大鼠脑中胆囊收缩素羧基末端八肽和四肽的浓度。硫酸化八肽是大鼠脑中胆囊收缩素的主要形式（约80%）。四肽的浓度以摩尔计占硫酸化八肽浓度的5%-10%，这取决于脑区。除了四肽外，还能检测到一种具有非硫酸化形式胆囊收缩素八肽特性的肽，其浓度与四肽相似。
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