儿茶酚-O-甲基转移酶与22q11.2缺失综合征患儿的焦虑及认知
COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.
作者信息
Shashi Vandana, Howard Timothy D, Keshavan Matcheri S, Kaczorowski Jessica, Berry Margaret N, Schoch Kelly, Spence Edward J, Kwapil Thomas R
机构信息
Duke University Medical Center, Division of Medical Genetics, Department of Pediatrics, Durham, North Carolina 27710, USA.
出版信息
Psychiatry Res. 2010 Jul 30;178(2):433-6. doi: 10.1016/j.psychres.2010.04.048. Epub 2010 May 20.
Abstract
The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
摘要
人们认为，儿茶酚-O-甲基转移酶（COMT）基因与22q11.2缺失综合征的认知/精神表型有关。我们在40名非精神病性22q11DS儿童中，针对COMT基因的缬氨酸（Val）/蛋氨酸（Met）等位基因测量了这些表现。Val等位基因与低智商、处理速度、执行功能以及更高频率的焦虑症相关，这突出了COMT基因在22q11DS儿童期精神病理学中的重要性。
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