在韩国人群中，WNT2 多态性与精神分裂症之间没有关联。
No association between polymorphisms of WNT2 and schizophrenia in a Korean population.
机构信息
College of Medicine, Soonchunhyang University, Chunan 336-745, Republic of Korea.
出版信息
BMC Med Genet. 2010 May 24;11:78. doi: 10.1186/1471-2350-11-78.
BACKGROUND
Wingless-type MMTV integration site family member 2 (WNT2) has a potentially important role in neuronal development; however, there has yet to be an investigation into the association between single nucleotide polymorphisms (SNPs) of WNT2 and schizophrenia. This study aimed to determine whether certain SNPs of WNT2 were associated with schizophrenia in a Korean population.
METHODS
e genotyped 7 selected SNPs in the WNT2 gene region (approximately 46 Kb) using direct sequencing in 288 patients with schizophrenia and 305 healthy controls.
RESULTS
Of the SNPs examined, one SNP showed a weak association with schizophrenia (p = 0.017 in the recessive model). However, this association did not remain statistically significant after Bonferroni correction.
CONCLUSION
The present study does not support a major role for WNT2 in schizophrenia. This could be due to the size of the population. Therefore, additional studies would be needed to definitively rule out the gene's minor effects.
背景
无翅型 MMV 整合位点家族成员 2（WNT2）在神经元发育中具有潜在的重要作用；然而，目前尚未研究 WNT2 的单核苷酸多态性（SNPs）与精神分裂症之间的关联。本研究旨在确定 WNT2 的某些 SNPs 是否与韩国人群中的精神分裂症有关。
方法
我们使用直接测序法对 288 名精神分裂症患者和 305 名健康对照者的 WNT2 基因区域（约 46 Kb）中的 7 个选定的 SNPs 进行了基因分型。
结果
在所检查的 SNP 中，一个 SNP 与精神分裂症呈弱关联（隐性模型中 p = 0.017）。然而，经过 Bonferroni 校正后，这种关联不再具有统计学意义。
结论
本研究不支持 WNT2 在精神分裂症中起主要作用。这可能是由于研究人群的规模。因此，需要进行更多的研究来明确排除该基因的微小作用。
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