神经甾体：啮齿动物脑中的3β-羟基-Δ(5)衍生物
Neuro-steroids: 3?-hydroxy-?(5)-derivatives in the rodent brain.
作者信息
Robel P, Baulieu E E
机构信息
CNRS ER 125 and INSERM U33, Lab Hormones, Faculté de Médecine, 94270 Bicêtre, France.
出版信息
Neurochem Int. 1985;7(6):953-8. doi: 10.1016/0197-0186(85)90143-3.
PMID:20493007
Abstract
Pregnenolone, dehydroepiandrosterone and their sulfate esters have been characterized in the rat brain. Their formation or accumulation depend on in situ mechanisms unrelated to the peripheral endocrine glands. Although their functions are still poorly understood, they may affect the brain by metabolism to sex steroid hormones and they may be functionally related to sexual behavior, possibly through direct modulations of the firing rates of neurons.
摘要
孕烯醇酮、脱氢表雄酮及其硫酸酯已在大鼠脑中得到表征。它们的形成或积累取决于与外周内分泌腺无关的原位机制。尽管对它们的功能仍知之甚少，但它们可能通过代谢为性甾体激素来影响大脑，并且它们可能在功能上与性行为相关，可能是通过直接调节神经元的放电频率。
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