5-羟色胺1A结合位点在大鼠脑桥背侧缝际核和中缝中央核中含5-羟色胺神经元上定位的证据。

Evidence for the localization of 5HT1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain.

作者信息

Weissmann-Nanopoulos D, Mach E, Magre J, Demassey Y, Pujol J F

机构信息

Département de Pharmacologie, Unité de Neuropharmacologie Centre de Recherches Roussel Uclaf 111, route de Noisy, 93230 Romainville, France.

出版信息

Neurochem Int. 1985;7(6):1061-72. doi: 10.1016/0197-0186(85)90156-1.

DOI:10.1016/0197-0186(85)90156-1

PMID:20493020

Abstract

Precise anatomical distribution of 5HT1 binding sites has been investigated in the nuclei raphe dorsalis, raphe centralis and locus caeruleus of the rat brain. An original pattern of distribution was observed in the raphe nuclei, closely correlated to the already known distribution of 5HT containing elements. This pattern, more pronounced when 5HT1A sites were labelled, completely disappeared after lesioning by 5, 7DHT indicating the presence of this subtype of 5HT1 binding sites on 5HT containing neurons. It is postulated that these 5HT1A sites correspond in these raphe nuclei to 5HT autoreceptors.

摘要

已对大鼠脑中缝背核、中缝中央核和蓝斑中5HT1结合位点的精确解剖分布进行了研究。在中缝核中观察到一种原始的分布模式，这与已知的含5HT元素的分布密切相关。当标记5HT1A位点时，这种模式更为明显，在用5,7 - DHT损伤后完全消失，表明在含5HT的神经元上存在这种5HT1结合位点亚型。据推测，这些中缝核中的5HT1A位点对应于5HT自身受体。