反向形态发生蛋白 INF2 进行分拣。

The inverted Formin INF2 sorts it out.

机构信息

Institute of Biophysical Chemistry, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

出版信息

Dev Cell. 2010 May 18;18(5):689-90. doi: 10.1016/j.devcel.2010.05.011.

DOI:10.1016/j.devcel.2010.05.011

PMID:20493801

Abstract

A new study published in this issue of Developmental Cell by Madrid et al. surprisingly reveals that both the actin polymerization and depolymerization activities of human inverted formin INF2 and its interactions with MAL2 and active Cdc42 are critical for basolateral-to-apical transcytosis and lumen formation in polarized epithelial cells.

摘要

马德里等人在本期《发育细胞》上发表的一项新研究令人惊讶地揭示，人类倒位formin INF2 的肌动蛋白聚合和去聚合活性及其与 MAL2 和活性 Cdc42 的相互作用，对于极化上皮细胞中的基底外侧到顶端转胞运输和腔形成是至关重要的。