Olga Tennison Autism Research Centre, School of Psychological Science, La Trobe University, Bundoora, VIC, Australia.
J Dev Behav Pediatr. 2010 Jun;31(5):376-85. doi: 10.1097/DBP.0b013e3181df7f3c.
Despite behavioral markers of autism spectrum disorders (ASDs) being evident within the first year of life, there remains little research on the prospective identification of these children in a community-based setting before 18 months. The aim in the Social Attention and Communication Study was to identify infants and toddlers at risk of an ASD during their first 2 years.
A total of 241 Maternal and Child Health nurses were trained on the early signs of ASDs at 8, 12, 18 and 24 months. Using a developmental surveillance approach with a community-based sample, a cohort of 20,770 children was monitored on early social attention and communication behaviors. Those infants/toddlers identified as "at risk" were referred to the Social Attention and Communication Study team from 12 months for developmental and diagnostic assessments at 6 monthly intervals, until 24 months.
A total of 216 children were referred, with 110 being further assessed. Of these, 89 children were classified with an ASD at 24 months, and 20 children had developmental and/or language delays, resulting in a Positive Predictive value of 81%. The estimated rate of ASDs in the Social Attention and Communication Study cohort ranged from 1:119 to 1:233 children. Estimated sensitivity ranged from 69% to 83.8%, and estimated specificity ranged from 99.8% to 99.9%.
Developmental surveillance of social and communication behaviors, which differ according to the age at which the child is monitored, enables the accurate identification of children at risk for ASDs between 12 and 24 months. Education on the early signs is recommended for all primary health care professionals to facilitate early identification of ASDs.
尽管自闭症谱系障碍(ASD)的行为标志物在生命的第一年就已经明显,但在 18 个月之前,在社区环境中对这些儿童进行前瞻性识别的研究仍然很少。在社会关注和沟通研究中的目标是在 2 年内识别有 ASD 风险的婴儿和幼儿。
共有 241 名母婴健康护士接受了 8、12、18 和 24 个月时 ASD 早期迹象的培训。使用基于社区的样本进行发育监测方法,对 20770 名儿童的早期社交注意力和沟通行为进行了监测。那些被认为“有风险”的婴儿/幼儿从 12 个月开始,由社会关注和沟通研究小组转介,每 6 个月进行一次发育和诊断评估,直到 24 个月。
共有 216 名儿童被转介,其中 110 名进一步接受评估。其中,89 名儿童在 24 个月时被诊断为 ASD,20 名儿童存在发育和/或语言延迟,阳性预测值为 81%。社会关注和沟通研究队列中 ASD 的估计发生率为 1:119 至 1:233 名儿童。估计的敏感性范围为 69%至 83.8%,估计的特异性范围为 99.8%至 99.9%。
对社交和沟通行为进行发育监测,根据监测儿童的年龄不同而有所不同,能够在 12 至 24 个月之间准确识别有 ASD 风险的儿童。建议为所有初级保健专业人员提供有关早期迹象的教育,以促进 ASD 的早期识别。